This is how I do it in Potion Maker:
Code:
<Tooltip name="PotionMakerTooltip" inherits="ZO_ItemIconTooltip" mouseEnabled="true" movable="true" hidden="true">
<ResizeToFitPadding width="48" height="57"/>
<DimensionConstraints minX="416" maxX="416" />
</Tooltip>
No issue with the size.