Little bug
 

is this: installed several add-ons. Now, everytime i open the normal Map, i cannot mark a destination. Pressing F will not mark a spot on the map. Only after I close the map and open it again I can mark as normal. This happens on every zone change/ws use.
Tried to fiddle with add-ons that influence the user-interface but couldn't narrow it down.

Any ideas? Help much appreciated.

This is most times a conflict between addons using map pings with and without LibMapPings (do not confuse with LibMapPins :))
Typical group data sharing addons and map addons.
Unfortunately it can be a timing problem. Just one addon too much and it happens. But you can not pinpoint a gulity.

Maybe post your addon list.