Yes they do, search for SavedVariables via google or read here:
https://www.esoui.com/forums/showthread.php?t=9235
Solution:
Disable addons you do not use all the time and just enabled when needed! Especially during dungeons/trials disable crafting related stuff etc.
You can use an addon like "Addon Selector" to save profiles of your addons and load them as needed with a few clicks.