[sirinsidiator]

Haven't tested this myself, but you could try something like this:

init:

local keybindButtonDescriptor = KEYBIND_STRIP.keybinds["UI_SHORTCUT_PRIMARY"]
local oldEnabled = keybindButtonDescriptor.enabled

disable:

keybindButtonDescriptor.enabled = false -- can also be a function that returns a boolean
KEYBIND_STRIP:UpdateKeybindButton(keybindButtonDescriptor)

enable:

keybindButtonDescriptor.enabled = oldEnabled
KEYBIND_STRIP:UpdateKeybindButton(keybindButtonDescriptor)

if this does not work, you could also replace keybindButtonDescriptor.callback with an empty function