I think there basically is no way to prevent the interaction. Most addons I know doing this kind of stuff hide the reticle but you'd still be able to use it.
The keybind code for that normally cannot be overwitten as it is local in teh ESOUI source code (or at least it was) and imo this is good :-) Else every 2nd addon would mess around with it and prevent anyone from turning in quests, etc.
But there are addons which prevent you from stealing items, like Dolgubons Lazy Writ Carfter (at turn in locaitons of writs -> steal items not allowed). Maybe check it's code how it is done there.
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