Game becoming unresponsive (Addon Issue)?

[Nameious]

I'm having an issue with my game at the moment. The issue is when I'm doing things IE using skill points searching guild store ect my game will bug out and what work (changing guild store, spending skill point) then my game becomes unresponsive and I can't do anything but attack. If i hit esc menu doesn't come up also using normal keyminds wont work in bank ect. Before I go through my massive addon list I wanted to ask if someone else had this issue with an addon. I've tried a few things so far I tried moving my saved variables folder no joy.